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Cerebral glucose metabolism Cerebral glucose metabolic rate with 18 F-fluoro-2-deoxyglucose ( 18 F-FDG) PET was observed in one RCT, which suggested a non-significant increase in CMR glc in all regions aside from the precuneus in the liraglutide group at the end of 6-month treatment period compared to baseline, whilst a decrease was seen in the precuneus, parietal, temporal, occipital lobe, cerebellum, and cingulate cortex in the placebo group at the end of treatment period compared to baseline [11]
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For researchers who need a well-characterized compound with existing literature support, Tirzepatide is typically the preferred choice in the Retatrutide vs Tirzepatide decision framework
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