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This ran contrary to official advice that American mothers should strictly abstain for nine months, and led to Oster being publicly rebuked by the American College of Obstetricians and Gynaecologists on the grounds that there is no known safe lower limit for alcohol in pregnancy (she still maintains that overly strict public health advice is likely to be ignored.) But this was more personal

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In clinical trials, the results were impressive: a median survival rate of 177.1 months for the early treatment Zycubo cohort compared with only 17.6 months for the untreated external cohort