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Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]
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Furthermore, GLP-1R likely modulates macrophage polarization toward the M2 phenotype, thereby contributing to its protective function in advancing coronary atherosclerosis [60]
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