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Since the use of animal insulin for the treatment of diabetes in 1922, about nine major classes of drugs for the treatment of diabetes have been discovered and developed worldwide, including sulfonylureas, biguanides, α-glucosidase inhibitors, insulins, thiazolidinediones (TZDs), meglitinides, GLP-1RAs, DPP-4 inhibitors, and SGLT-2 inhibitors
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