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McGraw-Hill / Lange rxlist.com (Onglyza ®) Keywords Linagliptin Trade Name: Tragenta ® Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Pharmacokinetics: biliary tract excretion - unique elimination route amongst the DPP-4 inhibitors useful for Type II diabetic patients with reduced renal function