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Oral GLP-1 Agonist Orforglipron Shows Promise for Type 2 Diabetes and Weight Management Kennedy Ferruggia, Associate Editor Key Takeaways Orforglipron, a novel oral GLP-1 receptor agonist, shows significant HbA1C reduction and weight loss in patients with T2D, with a safety profile similar to injectable GLP-1 drugs

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While some view these medications as transformative advances that legitimize obesity as a treatable disease, others worry that their increasing popularity could undermine longstanding efforts to deconstruct diet culture and promote body positivity