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There’s no single number that fits everyone, but a practical starting point for most adults on GLP-1 treatment is: 64–100 ounces (about 8–12 cups) of water per day , adjusted for body size, activity level, and climate An extra 8–16 ounces for every episode of vomiting or diarrhea More on days with exercise, heat exposure, or alcohol , since all three increase fluid loss Smaller, consistent sips throughout the day rather than large volumes at once, which is easier to tolerate when gastric emptying is already slowed A useful habit is to keep a marked water bottle nearby and treat drinking water as a scheduled action — tied to meals, medication days, or hourly reminders — rather than waiting for thirst, which may not reliably signal your actual needs while on a GLP-1 medication