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GLP-1 drugs and long-term use uncertainty
In a higher-dose form (as Wegovy), semaglutide is FDA-approved for weight management in those who are considered obese, or overweight with certain health risks
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In contrast, transient interactions between the exendin-P5 N-terminus and TMD are clearly important for agonism, with the majority of residues within this cavity being required for eliciting cAMP signalling (Figures 4-5, Supplemental Figure 10)
