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The presence of this side effect did not impact the drug's effectiveness, however
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However, electrophysiological studies revealed that GLP-1 or exendin-4 does not change the spontaneous firing activity as well as the synaptic transmission suggesting lack of functional GLP-1R in PPG neurons ( 2+ in 40% of NTS astrocytes, while selective inhibition of astrocyte function in NTS abolishes exendin-4-induced inhibition of food intake ( TABLE 1 Activation of GLP-1R suppresses feeding behaviors and modulates neuronal electrophysiological properties in several brain nuclei
