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A phase 2 trial investigated the effects of weekly injections of survodutide, a dual glucagon and GLP-1 receptor agonist, versus placebo in patients with biopsy-confirmed MASH and fibrosis stages F1–F3 over 48 weeks
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In addition, exendin-4 injection enhanced calcium signals in DMH GLP-1R neurons in the pre-ingestive stage, and exendin-4-induced pre-ingestive satiation was mitigated by optogenetic inhibition of DMH GLP-1R neurons
