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Perhaps even more persuasive (for the regulators) is the impact of GLP-1 drug on pouchitis (inflammation of the pouch)

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Although many treatments effective in animal models of IRI have failed to translate into clinical use, glucagon-like peptide 1 (GLP-1) and the GLP-1 receptor (GLP-1R) agonist exenatide have shown benefits in IRI in both animal models (4–7) and small early-phase clinical trials (8, 9)