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2 Effects of metformin on the gastrointestinal tract 2.1 Effects on glucose uptake and absorption PET-CT imaging-based studies have found that metformin modulates glucose in the intestine ( 18 F-FDG as a contrast agent, PET-CT technology was used to reflect changes in body metabolism through the uptake of the contrast agent by the lesion, where 18 F-FDG is a glucose analog that indicates the degree of glucose uptake and is generally used clinically to quantify tissue metabolism ( 18 F-FDG to T2DM patients treated with metformin, researchers showed that the amount of glucose entering the gastrointestinal system from the circulation was increased, which contributed to the drug’s glucose-lowering effect and improved glycemic control (Tobar et al., 2023)
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